Protein Details: Glutamate receptor ionotropic;kainate 1

Protein ID

ICDB_Pro_0515

Protein Name

Glutamate receptor ionotropic;kainate 1

Gene Name

GRIK1; GLUR5

Organism

Homo sapiens (Human)

Length

918 amino acids

AlphaFoldDB

AF-P39086-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel;gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change;leading to the opening of the cation channel;and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state;characterized by the presence of bound agonist. [Isoform 2]: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel;gated by L-glutamate and the glutamatergic agonist kainic acid.

Sequence

MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV

PDB Structures

2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 531; /ligand="L-glutamate"; BINDING 533; /ligand="L-glutamate"; BINDING 538; /ligand="L-glutamate"; BINDING 704; /ligand="L-glutamate"; BINDING 705; /ligand="L-glutamate"; BINDING 753; /ligand="L-glutamate"

Disease

Nondisjunction and Childhood Absence Epilepsy

Location

DOI ID

10.1097/00001756-199309150-00014; 10.1097/00001756-199412000-00055; 10.1113/jphysiol.1996.sp021295; 10.1016/j.jmb.2011.08.043; 10.1097/00041444-200109000-00005

RefSeq

NP_000821.1 [P39086-1]; NP_001307545.1; NP_001307547.1; NP_783300.1 [P39086-2]